diff --git a/gc.c b/gc.c
index 17bc9fde8c..d5ad47690f 100644
--- a/gc.c
+++ b/gc.c
@@ -3090,6 +3090,17 @@ Init_heap(void)
 {
     rb_objspace_t *objspace = &rb_objspace;
 
+#if defined(HAVE_SYSCONF) && defined(_SC_PAGE_SIZE)
+    /* If Ruby's heap pages are not a multiple of the system page size, we
+     * cannot use mprotect for the read barrier, so we must disable automatic
+     * compaction. */
+    int pagesize;
+    pagesize = (int)sysconf(_SC_PAGE_SIZE);
+    if ((HEAP_PAGE_SIZE % pagesize) != 0) {
+        ruby_enable_autocompact = 0;
+    }
+#endif
+
     objspace->next_object_id = INT2FIX(OBJ_ID_INITIAL);
     objspace->id_to_obj_tbl = st_init_table(&object_id_hash_type);
     objspace->obj_to_id_tbl = st_init_numtable();
@@ -9890,6 +9901,16 @@ gc_disable(rb_execution_context_t *ec, VALUE _)
 static VALUE
 gc_set_auto_compact(rb_execution_context_t *ec, VALUE _, VALUE v)
 {
+#if defined(HAVE_SYSCONF) && defined(_SC_PAGE_SIZE)
+    /* If Ruby's heap pages are not a multiple of the system page size, we
+     * cannot use mprotect for the read barrier, so we must disable automatic
+     * compaction. */
+    int pagesize;
+    pagesize = (int)sysconf(_SC_PAGE_SIZE);
+    if ((HEAP_PAGE_SIZE % pagesize) != 0) {
+        rb_raise(rb_eNotImpError, "Automatic compaction isn't available on this platform");
+    }
+#endif
     ruby_enable_autocompact = RTEST(v);
     return v;
 }
diff --git a/test/ruby/test_gc_compact.rb b/test/ruby/test_gc_compact.rb
index 3aad9e6d5f..4a8cff33f4 100644
--- a/test/ruby/test_gc_compact.rb
+++ b/test/ruby/test_gc_compact.rb
@@ -1,56 +1,82 @@
 # frozen_string_literal: true
 require 'test/unit'
 require 'fiddle'
+require 'etc'
 
 class TestGCCompact < Test::Unit::TestCase
-  def test_enable_autocompact
-    before = GC.auto_compact
-    GC.auto_compact = true
-    assert GC.auto_compact
-  ensure
-    GC.auto_compact = before
-  end
-
-  def test_disable_autocompact
-    before = GC.auto_compact
-    GC.auto_compact = false
-    refute GC.auto_compact
-  ensure
-    GC.auto_compact = before
-  end
-
-  def test_major_compacts
-    before = GC.auto_compact
-    GC.auto_compact = true
-    compact = GC.stat :compact_count
-    GC.start
-    assert_operator GC.stat(:compact_count), :>, compact
-  ensure
-    GC.auto_compact = before
-  end
-
-  def test_implicit_compaction_does_something
-    before = GC.auto_compact
-    list = []
-    list2 = []
-
-    # Try to make some fragmentation
-    500.times {
-      list << Object.new
-      Object.new
-      Object.new
-    }
-    count = GC.stat :compact_count
-    GC.auto_compact = true
-    loop do
-      break if count < GC.stat(:compact_count)
-      list2 << Object.new
+  class AutoCompact < Test::Unit::TestCase
+    def setup
+      skip "autocompact not supported on this platform" unless supports_auto_compact?
+      super
     end
-    compact_stats = GC.latest_compact_info
-    refute_predicate compact_stats[:considered], :empty?
-    refute_predicate compact_stats[:moved], :empty?
-  ensure
-    GC.auto_compact = before
+
+    def test_enable_autocompact
+      before = GC.auto_compact
+      GC.auto_compact = true
+      assert GC.auto_compact
+    ensure
+      GC.auto_compact = before
+    end
+
+    def test_disable_autocompact
+      before = GC.auto_compact
+      GC.auto_compact = false
+      refute GC.auto_compact
+    ensure
+      GC.auto_compact = before
+    end
+
+    def test_major_compacts
+      before = GC.auto_compact
+      GC.auto_compact = true
+      compact = GC.stat :compact_count
+      GC.start
+      assert_operator GC.stat(:compact_count), :>, compact
+    ensure
+      GC.auto_compact = before
+    end
+
+    def test_implicit_compaction_does_something
+      before = GC.auto_compact
+      list = []
+      list2 = []
+
+      # Try to make some fragmentation
+      500.times {
+        list << Object.new
+        Object.new
+        Object.new
+      }
+      count = GC.stat :compact_count
+      GC.auto_compact = true
+      loop do
+        break if count < GC.stat(:compact_count)
+        list2 << Object.new
+      end
+      compact_stats = GC.latest_compact_info
+      refute_predicate compact_stats[:considered], :empty?
+      refute_predicate compact_stats[:moved], :empty?
+    ensure
+      GC.auto_compact = before
+    end
+
+    private
+
+    def supports_auto_compact?
+      return true unless defined?(Etc::SC_PAGE_SIZE)
+
+      begin
+        return GC::INTERNAL_CONSTANTS[:HEAP_PAGE_SIZE] % Etc.sysconf(Etc::SC_PAGE_SIZE) == 0
+      rescue NotImplementedError
+      rescue ArgumentError
+      end
+
+      true
+    end
+  end
+
+  def os_page_size
+    return true unless defined?(Etc::SC_PAGE_SIZE)
   end
 
   def test_gc_compact_stats