diff --git a/compile.c b/compile.c
index c29d42e433..c62deafd23 100644
--- a/compile.c
+++ b/compile.c
@@ -1302,12 +1302,16 @@ static INSN *
 new_insn_send(rb_iseq_t *iseq, int line_no, ID id, VALUE argc, const rb_iseq_t *blockiseq, VALUE flag, struct rb_callinfo_kwarg *keywords)
 {
     VALUE *operands = compile_data_calloc2(iseq, sizeof(VALUE), 2);
-    operands[0] = (VALUE)new_callinfo(iseq, id, FIX2INT(argc), FIX2INT(flag), keywords, blockiseq != NULL);
+    VALUE ci = (VALUE)new_callinfo(iseq, id, FIX2INT(argc), FIX2INT(flag), keywords, blockiseq != NULL);
+    operands[0] = ci;
     operands[1] = (VALUE)blockiseq;
     if (blockiseq) {
         RB_OBJ_WRITTEN(iseq, Qundef, blockiseq);
     }
-    return new_insn_core(iseq, line_no, BIN(send), 2, operands);
+    INSN *insn = new_insn_core(iseq, line_no, BIN(send), 2, operands);
+    RB_OBJ_WRITTEN(iseq, Qundef, ci);
+    RB_GC_GUARD(ci);
+    return insn;
 }
 
 static rb_iseq_t *
diff --git a/test/ruby/test_gc.rb b/test/ruby/test_gc.rb
index daa8b5c37a..1f75a34cac 100644
--- a/test/ruby/test_gc.rb
+++ b/test/ruby/test_gc.rb
@@ -175,6 +175,16 @@ class TestGc < Test::Unit::TestCase
     assert_raise_with_message(ArgumentError, /\u{30eb 30d3 30fc}/) {GC.latest_gc_info(:"\u{30eb 30d3 30fc}")}
   end
 
+  def test_stress_compile_send
+    assert_in_out_err(%w[--disable-gems], <<-EOS, [], [], "")
+      GC.stress = true
+      begin
+        eval("A::B.c(1, 1, d: 234)")
+      rescue
+      end
+    EOS
+  end
+
   def test_singleton_method
     assert_in_out_err(%w[--disable-gems], <<-EOS, [], [], "[ruby-dev:42832]")
       GC.stress = true
diff --git a/version.h b/version.h
index 4dd36f0766..237c19e138 100644
--- a/version.h
+++ b/version.h
@@ -12,7 +12,7 @@
 # define RUBY_VERSION_MINOR RUBY_API_VERSION_MINOR
 #define RUBY_VERSION_TEENY 0
 #define RUBY_RELEASE_DATE RUBY_RELEASE_YEAR_STR"-"RUBY_RELEASE_MONTH_STR"-"RUBY_RELEASE_DAY_STR
-#define RUBY_PATCHLEVEL 20
+#define RUBY_PATCHLEVEL 21
 
 #define RUBY_RELEASE_YEAR 2021
 #define RUBY_RELEASE_MONTH 2