diff --git a/scss/_button-group.scss b/scss/_button-group.scss
index d7220029ad..e486d469d9 100644
--- a/scss/_button-group.scss
+++ b/scss/_button-group.scss
@@ -13,9 +13,7 @@
 
     // Bring the hover, focused, and "active" buttons to the front to overlay
     // the borders properly
-    @include hover {
-      z-index: 1;
-    }
+    &:hover,
     &:focus,
     &:active,
     &.active {
diff --git a/scss/_buttons.scss b/scss/_buttons.scss
index 5a684a3ff0..2adce28b47 100644
--- a/scss/_buttons.scss
+++ b/scss/_buttons.scss
@@ -17,7 +17,7 @@
   @include button-size($btn-padding-y, $btn-padding-x, $btn-font-size, $btn-line-height, $btn-border-radius);
   @include transition($btn-transition);
 
-  @include hover {
+  &:hover {
     color: $body-color;
     text-decoration: none;
   }
@@ -79,7 +79,7 @@ fieldset:disabled a.btn {
   color: $btn-link-color;
   text-decoration: $link-decoration;
 
-  @include hover {
+  &:hover {
     color: $btn-link-hover-color;
     text-decoration: $link-hover-decoration;
   }
diff --git a/scss/_card.scss b/scss/_card.scss
index c0b2078c1c..5deefeeed6 100644
--- a/scss/_card.scss
+++ b/scss/_card.scss
@@ -53,7 +53,7 @@
 }
 
 .card-link {
-  @include hover {
+  &:hover {
     text-decoration: none;
   }
 
diff --git a/scss/_carousel.scss b/scss/_carousel.scss
index 20ea04baf4..0635a4acd5 100644
--- a/scss/_carousel.scss
+++ b/scss/_carousel.scss
@@ -101,7 +101,8 @@
   @include transition($carousel-control-transition);
 
   // Hover/focus state
-  @include hover-focus {
+  &:hover,
+  &:focus {
     color: $carousel-control-color;
     text-decoration: none;
     outline: 0;
diff --git a/scss/_close.scss b/scss/_close.scss
index 5cc96f573e..4f92022c87 100644
--- a/scss/_close.scss
+++ b/scss/_close.scss
@@ -8,13 +8,14 @@
   opacity: .5;
 
   // Override <a>'s hover style
-  @include hover {
+  &:hover {
     color: $close-color;
     text-decoration: none;
   }
 
   &:not(:disabled):not(.disabled) {
-    @include hover-focus {
+    &:hover,
+    &:focus {
       opacity: .75;
     }
   }
diff --git a/scss/_dropdown.scss b/scss/_dropdown.scss
index ba8674e929..3f46641541 100644
--- a/scss/_dropdown.scss
+++ b/scss/_dropdown.scss
@@ -143,7 +143,8 @@
     }
   }
 
-  @include hover-focus {
+  &:hover,
+  &:focus {
     color: $dropdown-link-hover-color;
     text-decoration: none;
     @include gradient-bg($dropdown-link-hover-bg);
diff --git a/scss/_list-group.scss b/scss/_list-group.scss
index 3f80687ab4..71edfb2d34 100644
--- a/scss/_list-group.scss
+++ b/scss/_list-group.scss
@@ -23,7 +23,8 @@
   text-align: inherit; // For `<button>`s (anchors inherit)
 
   // Hover state
-  @include hover-focus {
+  &:hover,
+  &:focus {
     z-index: 1; // Place hover/focus items above their siblings for proper border styling
     color: $list-group-action-hover-color;
     text-decoration: none;
diff --git a/scss/_mixins.scss b/scss/_mixins.scss
index afbdd6ff5e..a8be120638 100644
--- a/scss/_mixins.scss
+++ b/scss/_mixins.scss
@@ -10,7 +10,6 @@
 
 // Utilities
 @import "mixins/breakpoints";
-@import "mixins/hover";
 @import "mixins/image";
 @import "mixins/resize";
 @import "mixins/screen-reader";
diff --git a/scss/_nav.scss b/scss/_nav.scss
index 2085d06f67..6d77aeba86 100644
--- a/scss/_nav.scss
+++ b/scss/_nav.scss
@@ -15,7 +15,8 @@
   display: block;
   padding: $nav-link-padding-y $nav-link-padding-x;
 
-  @include hover-focus {
+  &:hover,
+  &:focus {
     text-decoration: none;
   }
 
@@ -42,7 +43,8 @@
     border: $nav-tabs-border-width solid transparent;
     @include border-top-radius($nav-tabs-border-radius);
 
-    @include hover-focus {
+    &:hover,
+    &:focus {
       border-color: $nav-tabs-link-hover-border-color;
     }
 
diff --git a/scss/_navbar.scss b/scss/_navbar.scss
index 8f52bdd173..b1efa0c04a 100644
--- a/scss/_navbar.scss
+++ b/scss/_navbar.scss
@@ -48,7 +48,8 @@
   line-height: inherit;
   white-space: nowrap;
 
-  @include hover-focus {
+  &:hover,
+  &:focus {
     text-decoration: none;
   }
 }
@@ -112,7 +113,8 @@
   border: $border-width solid transparent; // remove default button style
   @include border-radius($navbar-toggler-border-radius);
 
-  @include hover-focus {
+  &:hover,
+  &:focus {
     text-decoration: none;
   }
 }
@@ -193,7 +195,8 @@
   .navbar-brand {
     color: $navbar-light-brand-color;
 
-    @include hover-focus {
+    &:hover,
+    &:focus {
       color: $navbar-light-brand-hover-color;
     }
   }
@@ -202,7 +205,8 @@
     .nav-link {
       color: $navbar-light-color;
 
-      @include hover-focus {
+      &:hover,
+      &:focus {
         color: $navbar-light-hover-color;
       }
 
@@ -230,12 +234,11 @@
 
   .navbar-text {
     color: $navbar-light-color;
-    a {
-      color: $navbar-light-active-color;
 
-      @include hover-focus {
-        color: $navbar-light-active-color;
-      }
+    a,
+    a:hover,
+    a:focus  {
+      color: $navbar-light-active-color;
     }
   }
 }
@@ -245,7 +248,8 @@
   .navbar-brand {
     color: $navbar-dark-brand-color;
 
-    @include hover-focus {
+    &:hover,
+    &:focus {
       color: $navbar-dark-brand-hover-color;
     }
   }
@@ -254,7 +258,8 @@
     .nav-link {
       color: $navbar-dark-color;
 
-      @include hover-focus {
+      &:hover,
+      &:focus {
         color: $navbar-dark-hover-color;
       }
 
@@ -282,12 +287,10 @@
 
   .navbar-text {
     color: $navbar-dark-color;
-    a {
+    a,
+    a:hover,
+    a:focus {
       color: $navbar-dark-active-color;
-
-      @include hover-focus {
-        color: $navbar-dark-active-color;
-      }
     }
   }
 }
diff --git a/scss/_reboot.scss b/scss/_reboot.scss
index 67ecd9e275..df3eacbff8 100644
--- a/scss/_reboot.scss
+++ b/scss/_reboot.scss
@@ -219,7 +219,7 @@ a {
   text-decoration: $link-decoration;
   background-color: transparent; // Remove the gray background on active links in IE 10.
 
-  @include hover {
+  &:hover {
     color: $link-hover-color;
     text-decoration: $link-hover-decoration;
   }
@@ -232,15 +232,11 @@ a {
 // See https://github.com/twbs/bootstrap/issues/19402
 
 a:not([href]):not([tabindex]) {
-  color: inherit;
-  text-decoration: none;
-
-  @include hover-focus {
+  &,
+  &:hover,
+  &:focus {
     color: inherit;
     text-decoration: none;
-  }
-
-  &:focus {
     outline: 0;
   }
 }
diff --git a/scss/_tables.scss b/scss/_tables.scss
index b7ab3d5062..756c071a79 100644
--- a/scss/_tables.scss
+++ b/scss/_tables.scss
@@ -84,7 +84,7 @@
 
 .table-hover {
   tbody tr {
-    @include hover {
+    &:hover {
       color: $table-hover-color;
       background-color: $table-hover-bg;
     }
@@ -149,7 +149,7 @@
 
   &.table-hover {
     tbody tr {
-      @include hover {
+      &:hover {
         color: $table-dark-hover-color;
         background-color: $table-dark-hover-bg;
       }
diff --git a/scss/_variables.scss b/scss/_variables.scss
index e2271491d5..9d3f69c157 100644
--- a/scss/_variables.scss
+++ b/scss/_variables.scss
@@ -112,7 +112,6 @@ $enable-shadows:                              false !default;
 $enable-gradients:                            false !default;
 $enable-transitions:                          true !default;
 $enable-prefers-reduced-motion-media-query:   true !default;
-$enable-hover-media-query:                    false !default; // Deprecated, no longer affects any compiled CSS
 $enable-grid-classes:                         true !default;
 $enable-pointer-cursor-for-buttons:           true !default;
 $enable-print-styles:                         true !default;
diff --git a/scss/mixins/_buttons.scss b/scss/mixins/_buttons.scss
index 874f552d0c..1c51765d22 100644
--- a/scss/mixins/_buttons.scss
+++ b/scss/mixins/_buttons.scss
@@ -9,7 +9,7 @@
   border-color: $border;
   @include box-shadow($btn-box-shadow);
 
-  @include hover {
+  &:hover {
     color: color-yiq($hover-background);
     @include gradient-bg($hover-background);
     border-color: $hover-border;
@@ -65,7 +65,7 @@
   color: $color;
   border-color: $color;
 
-  @include hover {
+  &:hover {
     color: $color-hover;
     background-color: $active-background;
     border-color: $active-border;
diff --git a/scss/mixins/_hover.scss b/scss/mixins/_hover.scss
deleted file mode 100644
index 192f847e17..0000000000
--- a/scss/mixins/_hover.scss
+++ /dev/null
@@ -1,37 +0,0 @@
-// Hover mixin and `$enable-hover-media-query` are deprecated.
-//
-// Originally added during our alphas and maintained during betas, this mixin was
-// designed to prevent `:hover` stickiness on iOS-an issue where hover styles
-// would persist after initial touch.
-//
-// For backward compatibility, we've kept these mixins and updated them to
-// always return their regular pseudo-classes instead of a shimmed media query.
-//
-// Issue: https://github.com/twbs/bootstrap/issues/25195
-
-@mixin hover {
-  &:hover { @content; }
-}
-
-@mixin hover-focus {
-  &:hover,
-  &:focus {
-    @content;
-  }
-}
-
-@mixin plain-hover-focus {
-  &,
-  &:hover,
-  &:focus {
-    @content;
-  }
-}
-
-@mixin hover-focus-active {
-  &:hover,
-  &:focus,
-  &:active {
-    @content;
-  }
-}
diff --git a/scss/mixins/_list-group.scss b/scss/mixins/_list-group.scss
index cd47a4e9fa..965fc4bd87 100644
--- a/scss/mixins/_list-group.scss
+++ b/scss/mixins/_list-group.scss
@@ -6,7 +6,8 @@
     background-color: $background;
 
     &.list-group-item-action {
-      @include hover-focus {
+      &:hover,
+      &:focus {
         color: $color;
         background-color: darken($background, 5%);
       }
diff --git a/scss/mixins/_table-row.scss b/scss/mixins/_table-row.scss
index f8d61869a4..517229e1a7 100644
--- a/scss/mixins/_table-row.scss
+++ b/scss/mixins/_table-row.scss
@@ -26,7 +26,7 @@
     $hover-background: darken($background, 5%);
 
     .table-#{$state} {
-      @include hover {
+      &:hover {
         background-color: $hover-background;
 
         > td,
diff --git a/scss/mixins/_text-emphasis.scss b/scss/mixins/_text-emphasis.scss
index 155d6ca8cf..4c68bae89e 100644
--- a/scss/mixins/_text-emphasis.scss
+++ b/scss/mixins/_text-emphasis.scss
@@ -8,7 +8,8 @@
   }
   @if $emphasized-link-hover-darken-percentage != 0 {
     a#{$parent} {
-      @include hover-focus {
+      &:hover,
+      &:focus {
         color: darken($color, $emphasized-link-hover-darken-percentage) !important;
       }
     }
diff --git a/site/content/docs/4.3/migration.md b/site/content/docs/4.3/migration.md
index 278abd6cf2..d06c3f703a 100644
--- a/site/content/docs/4.3/migration.md
+++ b/site/content/docs/4.3/migration.md
@@ -22,6 +22,7 @@ See the browser and devices page for details on what is currently supported in B
 
 Changes to our source Sass files and compiled CSS.
 
+- Removed `hover`, `hover-focus`, `plain-hover-focus`, and `hover-focus-active` mixins. Use regular CSS syntax for these moving forward. [See #28267](https://github.com/twbs/bootstrap/pull/28267).
 - **Todo:** Remove previously deprecated mixins
   - `float()`
   - `form-control-mixin()`
diff --git a/site/static/docs/4.3/assets/scss/_skippy.scss b/site/static/docs/4.3/assets/scss/_skippy.scss
index db971d114c..ab59339d04 100644
--- a/site/static/docs/4.3/assets/scss/_skippy.scss
+++ b/site/static/docs/4.3/assets/scss/_skippy.scss
@@ -6,7 +6,7 @@
   background-color: $bd-purple;
   outline: 0;
 
-  @include hover {
+  &:hover {
     color: $white;
   }
 }